The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review.

ABSTRACT:

Background

The management of articular cartilage defects presents many clinical challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation techniques, such as microfracture, are the most frequently used method in clinical practice however the resulting mixed fibrocartilage tissue which is inferior to native hyaline cartilage. Other methods have shown promise but are far from perfect. There is an unmet need and growing interest in regenerative medicine and tissue engineering to improve the outcome for patients requiring cartilage repair. Many published reviews on cartilage repair only list human clinical trials, underestimating the wealth of basic sciences and animal studies that are precursors to future research. We therefore set out to perform a system

SUBMITTER: Goldberg A 

PROVIDER: S-EPMC5345159 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature