Region-specific effects of oestradiol on adipose-derived stem cell differentiation in post-menopausal women.

ABSTRACT: The goal of this study was to determine the effect of acute transdermal 17β-oestradiol (E₂ ) on the adipogenic potential of subcutaneous adipose-derived stem cells (ASC) in post-menopausal women. Post-menopausal women (n = 11; mean age 57 ± 4.5 years) were treated for 2 weeks, in a randomized, cross-over design, with transdermal E₂ (0.15 mg) or placebo patches. Biopsies of abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) were obtained after each treatment and mature adipocytes were analysed for cell size and ASC for their capacity for proliferation (growth rate), differentiation (triglyceride accumulation) and susceptibility to tumour necrosis factor alpha-induced apoptosis. Gene expression of oestrogen receptors α and β (ESR1 and ESR2), perilipin 1

SUBMITTER: Cox-York KA 

PROVIDER: S-EPMC5345675 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature