A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans.

ABSTRACT: When mutations have small effects on fitness, population size plays an important role in determining the amount and nature of deleterious genetic variation. The extent to which recent population size changes have impacted deleterious variation in humans has been a question of considerable interest and debate. An emerging consensus is that the Out-of-Africa bottleneck and subsequent growth events have been too short to cause meaningful differences in genetic load between populations; though changes in the number and average frequencies of deleterious variants have taken place. To provide more support for this view and to offer additional insight into the divergent evolution of deleterious variation across populations, we numerically solve time-inhomogeneous diffusion equations and study the

SUBMITTER: Koch E 

PROVIDER: S-EPMC5345704 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature