Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children.

ABSTRACT: In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria. As this invasion process represents a critical step during infection with the parasite, it was hypothesized that genetic variants in the gene could affect severe malaria (SM) susceptibility. We performed high-resolution variant discovery of rare and common genetic variants in the human CD55 gene. Association testing of these variants in over 1700 SM cases and unaffected control individuals from the malaria-endemic Ashanti Region in Ghana, West Africa, were performed on the basis of single variants, combined rare variant analyses, and reconstructed haplotypes. A total of 26 ge

SUBMITTER: Schuldt K 

PROVIDER: S-EPMC5345716 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature