Predictors and brain connectivity changes associated with arm motor function improvement from intensive practice in chronic stroke.

ABSTRACT: Background and Purpose: The brain changes that underlie therapy-induced improvement in motor function after stroke remain obscure. This study sought to demonstrate the feasibility and utility of measuring motor system physiology in a clinical trial of intensive upper extremity rehabilitation in chronic stroke-related hemiparesis. Methods: This was a substudy of two multi-center clinical trials of intensive robotic and intensive conventional therapy arm therapy in chronic, significantly hemiparetic, stroke patients. Transcranial magnetic stimulation was used to measure motor cortical output to the biceps and extensor digitorum communus muscles. Magnetic resonance imaging (MRI) was used to determine the cortical anatomy, as well as to measure fractional anisotropy, and blood ox

SUBMITTER: Wittenberg GF 

PROVIDER: S-EPMC5345776 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature