IL-10 distinguishes a unique population of activated, effector-like CD8⁺ T cells in murine acute liver inflammation.

ABSTRACT: Immune-mediated liver injury is a central feature of hyperinflammatory diseases, such as hemophagocytic syndromes, yet the immunologic mechanisms underlying those processes are incompletely understood. In this study, we used the toll-like receptor 9 (TLR9)-mediated model of a hemophagocytic syndrome known as macrophage activation syndrome (MAS) to dissect the predominant immune cell populations infiltrating the liver during inflammation. We identified CD8⁺ T cells that unexpectedly produce interleukin-10 (IL-10) in addition to interferon-γ (IFN-γ) as a major hepatic population induced by TLR9 stimulation. Despite their ability to produce this anti-inflammatory cytokine, IL-10⁺ hepatic CD8⁺ T cells in TLR9-MAS mice did not resemble CD8⁺ T suppress

SUBMITTER: Rood JE 

PROVIDER: S-EPMC5346180 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature