Assessment of treatment response in non-alcoholic steatohepatitis using advanced magnetic resonance imaging.

ABSTRACT:

Background

Magnetic resonance imaging-derived measures of liver fat and volume are emerging as accurate, non-invasive imaging biomarkers in non-alcoholic steatohepatitis (NASH). Little is known about these measures in relation to histology longitudinally.

Aim

To examine any relationship between MRI-derived proton-density fat-fraction (PDFF), total liver volume (TLV), total liver fat index (TLFI), vs. histology in a NASH trial.

Methods

This is a secondary analysis of a 24-week randomised, double-blind, placebo-controlled trial of 50 patients with biopsy-proven NASH randomised to oral ezetimibe 10 mg daily (n = 25) vs. placebo (n = 25). Baseline and post-treatment anthropometrics, biochemical profiling, MRI and biopsies were obtained.

Results

Baseline mean PDFF c

SUBMITTER: Lin SC 

PROVIDER: S-EPMC5346270 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature