GATA3 Gene Polymorphisms Associated with Allergic Rhinitis in an Iranian Population.

ABSTRACT:

Background

The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA3 single nucleotide polymorphisms and AR in an Iranian population was identified.

Methods

This case-control study was performed on 86 patients with AR and 86 healthy subjects. This study aimed to evaluate a potential association between two GATA3 SNPs, rs1269486 and rs2229360, and AR. Blood samples were collected and DNA was extracted for the evaluation of these SNPs by RFLP-PCR.

Results

A statistically-significant association was found between rs1269486 and AR (P<0.001). The frequencies of the A and GA genotypes were less in patients than in controls. The frequencies of the

SUBMITTER: Shirkani A 

PROVIDER: S-EPMC5346276 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature