Differential bicodon usage in lowly and highly abundant proteins.

ABSTRACT: Degeneracy in the genetic code implies that different codons can encode the same amino acid. Usage preference of synonymous codons has been observed in all domains of life. There is much evidence suggesting that this bias has a major role on protein elongation rate, contributing to differential expression and to co-translational folding. In addition to codon usage bias, other preference variations have been observed such as codon pairs. In this paper, I report that codon pairs have significant different frequency usage for coding either lowly or highly abundant proteins. These usage preferences cannot be explained by the frequency usage of the single codons. The statistical analysis of coding sequences of nine organisms reveals that in many cases bicodon preferences are shared between rela

SUBMITTER: Diambra LA 

PROVIDER: S-EPMC5346287 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature