Cocaine Use Reverses Striatal Plasticity Produced During Cocaine Seeking.

ABSTRACT:

Background

Relapse is a two-component process consisting of a highly motivated drug-seeking phase that, if successful, is followed by a drug-using phase resulting in temporary satiation. In rodents, cue-induced drug seeking requires transient synaptic potentiation (t-SP) of cortical glutamatergic synapses on nucleus accumbens core medium spiny neurons, but it is unknown how achieving drug use affects this plasticity. We modeled the two phases of relapse after extinction from cocaine self-administration to assess how cocaine use affects t-SP associated with cue-induced drug seeking.

Methods

Rats were trained to self-administer cocaine (n = 96) or were used as yoked-saline control animals (n = 21). After extinction, reinstatement was initiated by 10 minutes of cue-induced drug

SUBMITTER: Spencer S 

PROVIDER: S-EPMC5346331 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature