Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features.

ABSTRACT:

Background

Severe asthma in children is a heterogeneous disorder associated with variable responses to corticosteroid treatment. Criterion standards for corticosteroid responsiveness assessment in children are lacking.

Objective

This study sought to characterize systemic corticosteroid responses in children with severe asthma after treatment with intramuscular triamcinolone and to identify phenotypic and molecular predictors of an intramuscular triamcinolone response.

Methods

Asthma-related quality of life, exhaled nitric oxide, blood eosinophils, lung function, and inflammatory cytokine and chemokine mRNA gene expression in peripheral blood mononuclear cells were assessed in 56 children with severe asthma at baseline and 14 days after intramuscular triamcinolone inje

SUBMITTER: Fitzpatrick AM 

PROVIDER: S-EPMC5346343 | biostudies-literature | 2017 Mar - Apr

REPOSITORIES: biostudies-literature