Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice.

ABSTRACT: Exercise is known to have numerous beneficial effects. Recent studies indicate that exercise improves mitochondrial energetics not only in skeletal muscle but also in other tissues. While exercise elicits positive effects on memory, neurogenesis, and synaptic plasticity, the effects of exercise on brain mitochondrial energetics remain relatively unknown. Herein, we studied the effects of exercise training in old and young mice on brain mitochondrial energetics, in comparison to known effects on peripheral tissues that utilize fatty acid oxidation. Exercise improved the capacity for muscle and liver to oxidize palmitate in old mice, but not young mice. In the brain, exercise increased rates of respiration and reactive oxygen species (ROS) production in the old group only while utilizing com

SUBMITTER: Gusdon AM 

PROVIDER: S-EPMC5346470 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature