MxA mRNA decrease preceding NAb detection in IFNβ-treated MS patients.

ABSTRACT:

Background

Multiple sclerosis (MS) patients treated with interferon beta (IFNβ) are at risk of a declining response to treatment because of the production of IFNβ-neutralizing antibodies (NAbs). The expression of Myxovirus resistance protein A (MxA) mRNA is regarded as a marker of IFNβ bioactivity.

Aims

The aim of this study was to analyze the kinetics of MxA mRNA expression during long-term IFNβ treatment and assess its relationship to NAb production.

Methods

A prospective, observational, open-label, non-randomized study was designed in multiple sclerosis patients starting IFNβ treatment. NAbs and MxA mRNA were monitored every six months.

Results

119 patients were consecutively enrolled and 107 were included in the final analysis. Both the presence of NAbs and

SUBMITTER: Libertinova J 

PROVIDER: S-EPMC5346526 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature