CCR10/CCL27 crosstalk contributes to failure of proteasome-inhibitors in multiple myeloma.

ABSTRACT: The bone marrow microenvironment plays a decisive role in multiple myeloma progression and drug resistance. Chemokines are soluble mediators of cell migration, proliferation and survival and essentially modulate tumor progression and drug resistance. Here we investigated bone marrow-derived chemokines of naive and therapy-refractory myeloma patients and discovered that high levels of the chemokine CCL27, known so far for its role in skin inflammatory processes, correlated with worse overall survival of the patients. In addition, chemokine levels were significantly higher in samples from patients who became refractory to bortezomib at first line treatment compared to resistance at later treatment lines.In vitro as well as in an in vivo model we could show that CCL27 triggers bortezomib-resi

SUBMITTER: Thangavadivel S 

PROVIDER: S-EPMC5346663 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature