Diagnostic accuracy of DNA methylation for head and neck cancer varies by sample type and number of markers tested.

ABSTRACT: Abnormal methylation of certain cancer related genes strongly predicts a diagnosis of head and neck cancer (HNC), while the predictive power of methylation of other DNA markers for HNC remains unclear. To systemically assess the diagnostic value of DNA methylation patterns for HNC and the effect of methylation platform techniques and sample types, we performed a PubMed search for studies of the correlation between DNA methylation and HNC completed before July 2016, and extracted the sensitivity and specificity for methylated biomarkers. Across these studies, DNA methylation showed high sensitivity for diagnosing HNC in solid tissue (0.57), and high specificity in saliva (0.89). Area under the curve (AUC) from summary receiver operating characteristic (SROC) curves revealed that DNA methyla

SUBMITTER: Ji X 

PROVIDER: S-EPMC5346768 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature