TGF-β1 polymorphisms -509 C>T and +915 G>C and risk of pancreatic cancer.

ABSTRACT:

Background

Ninety percent of pancreatic cancer patients have less than 5-year overall survival and approximately 50% of cases were diagnosed with metastasis in the time of admission. Previous evidences have demonstrated the strong association between TGF-β1 variations and cancer susceptibility so far.

Methods

A total of 78 patients with pancreatic cancer and 94 healthy controls were enrolled in this case- control study between 2007 and 2012. Genomic DNA was isolated from peripheral blood samples according to phenol chloroform extraction. The genotypes of TGF-β1 rs rs1800469 and rs1800471 were determined using the polymerase chain reaction-restriction fragment length polymorphism method.

Results

The mean age of cases and the control group were 64.50 ± 13.718 and 40.12

SUBMITTER: Behboudi Farahbakhsh F 

PROVIDER: S-EPMC5346819 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature