Polymorphism of IFN-γ (+874 T/A) in Syrian patients with chronic hepatitis B.

ABSTRACT:

Aim

This study aimed to investigate the association of IFN- γ +874 (T/A) polymorphism with susceptibility to chronic HBV infection in the Syrian population.

Background

Accumulating evidence indicate that the inadequate immune responses are responsible for HBV persistency. Therefore, polymorphisms in genes encoding the cytokines, which are responsible for regulation of the immune response, can affect the course and outcome of the infection. The IFN-γ +874 T/A polymorphism affects the expression of IFN-γ, which has been shown to be crucial to HBV clearance.

Methods

In this case-control study, 140 samples were collected (70 healthy individuals, 70 chronic HBV patients), and genomic DNA was isolated. Sequencing and ARMS-PCR were performed to genotype the IFN-γ +874 T/A po

SUBMITTER: Al Kadi M 

PROVIDER: S-EPMC5346822 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature