Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity.

ABSTRACT:

Adverse event

A drug interaction leading to severe skin and mucosal toxicity.

Drugs implicated

Paclitaxel, docetaxel and amiodarone.

The patient

A 77-year-old woman with a history of hypertension, hyperlipidemia, and palpitations, managed with amiodarone, was treated for HER2-positive invasive ductal breast cancer with paclitaxel and trastuzumab as an adjunct to surgery.

Evidence that links the drug to the event

There was a strong temporal relationship between the taxane therapy and the development of severe skin and mucosal toxicity due to an unexpected reduction in taxane clearance.

Management

Initially, conversion of paclitaxel to docetaxel, then cessation of docetaxel, symptomatic treatment, rehydration and placement of a nasogastric tube.

Mechani

SUBMITTER: Hammann F 

PROVIDER: S-EPMC5346859 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature