Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation.

ABSTRACT:

Aims

Despite longstanding recognition of significant age-dependent differences in drug disposition during childhood, the exact course and the underlying mechanisms are not known. Our aim was to determine the course and determinants of individual relative dose requirements, during long-term follow-up in children on tacrolimus.

Methods

This was a cohort study in a tertiary hospital with standardized annual pharmacokinetic (PK) follow-up (AUC_0-12hr ) in recipients of a renal allograft (≤19 years), between 1998 and 2015. In addition, the presence of relevant pharmacogenetic variants was determined. The evolution of dose-corrected exposure was evaluated using mixed models.

Results

A total of 184 PK visits by 43 children were included in the study (median age: 14

SUBMITTER: Knops N 

PROVIDER: S-EPMC5346878 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature