Scaling clearance in paediatric pharmacokinetics: All models are wrong, which are useful?

ABSTRACT:

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This article is commented on in the editorial by Holford NHG and Anderson BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685-7. doi: 10.1111/bcp.13230 AIM: When different models for weight and age are used in paediatric pharmacokinetic studies it is difficult to compare parameters between studies or perform model-based meta-analyses. This study aimed to compare published models with the proposed standard model (allometric weight^0.75 and sigmoidal maturation function).

Methods

A systematic literature search was undertaken to identify published clearance (CL) reports for gentamicin and midazolam and all published models for scaling clearance in children. Each model was fitted to the CL values for gentamicin and midaz

SUBMITTER: Germovsek E 

PROVIDER: S-EPMC5346879 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature