Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation.

ABSTRACT: Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism specifically impact neuronal intracellular processes and cause neuropathological events is still unclear. We here dissect the molecular mechanism by which mitochondrial dysfunction induced by Prel aberrant function mediates selective dendritic loss in Drosophila melanogaster class IV dendritic arborization neurons. Using in vivo ATP imaging, we found that neuronal cellular ATP levels during development are not correlated with the progression of dendritic loss. We searched for mitochondrial stress signaling pathways that induce dendritic loss and found that mitochondrial dysfunction is associated with increased eIF2α phosphorylat

SUBMITTER: Tsuyama T 

PROVIDER: S-EPMC5346966 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature