Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez Camargo DC
PROVIDER: S-EPMC5347123 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20170313
Type II diabetes (T2D) is characterized by diminished insulin production and resistance of cells to insulin. Among others, endoplasmic reticulum (ER) stress is a principal factor contributing to T2D and induces a shift towards a more reducing cellular environment. At the same time, peripheral insulin resistance triggers the over-production of regulatory hormones such as insulin and human islet amyloid polypeptide (hIAPP). We show that the differential aggregation of reduced and oxidized hIAPP as ...[more]