Lethal Consequences of Overcoming Metabolic Restrictions Imposed on a Cooperative Bacterial Population.

ABSTRACT: Quorum sensing (QS) controls cooperative activities in many Proteobacteria In some species, QS-dependent specific metabolism contributes to the stability of the cooperation. However, the mechanism by which QS and metabolic networks have coevolved to support stable public good cooperation and maintenance of the cooperative group remains unknown. Here we explored the underlying mechanisms of QS-controlled central metabolism in the evolutionary aspects of cooperation. In Burkholderia glumae, the QS-dependent glyoxylate cycle plays an important role in cooperativity. A bifunctional QS-dependent transcriptional regulator, QsmR, rewired central metabolism to utilize the glyoxylate cycle rather than the tricarboxylic acid cycle. Defects in the glyoxylate cycle caused metabolic imbal

SUBMITTER: Goo E 

PROVIDER: S-EPMC5347341 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature