Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer.

ABSTRACT: There is compelling biological data to suggest that cancer arises from a series of mutations in single target cells, resulting in defects in cell renewal and differentiation processes which lead to malignancy. Because much mutagenic damage is expressed following cell division, more-rapidly renewing tissues could be at higher risk because of the larger number of cell replications. Cairns suggested that renewing tissues may reduce cancer risk by partitioning the dividing cell populations into lineages comprising infrequently-dividing long-lived stem cells and frequently-dividing short-lived daughter transit cells. We develop generalizations of three recent cancer-induction models that account for the joint maintenance and renewal of stem and transit cells, also competing processes of partial

SUBMITTER: Little MP 

PROVIDER: S-EPMC5347390 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature