Ontology highlight
ABSTRACT:
SUBMITTER: Shi G
PROVIDER: S-EPMC5347682 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Shi Gongping G Yoshida Yoko Y Yuki Kanako K Nishimura Tomomi T Kawata Yukiko Y Kawashima Masahiro M Iwaisako Keiko K Yoshikawa Kiyotsugu K Kurebayashi Junichi J Toi Masakazu M Noda Makoto M
Oncotarget 20161201 50
The membrane-anchored glycoprotein RECK negatively regulates multiple metalloproteinases and is frequently downregulated in tumors. Forced RECK expression in cancer cells results in suppression of tumor angiogenesis, invasion, and metastasis in xenograft models. A previous methylome study on breast cancer tissues detected inverse correlation between RECK CpG methylation (in an intron-1 region) and relapse-free survival. In this study, we focused on another region of the RECK CpG island (a promot ...[more]