Idiopathic male infertility in the Han population in China is affected by polymorphism in the VDAC2 gene.

ABSTRACT:

Background

It has been proved that human voltage-dependent anion channel 2 (VDAC2) plays a significant role in sperm function and male fertility. This study was primarily aimed at exploring whether VDAC2 is a risk factor for idiopathic male infertility.

Results

We determined a significantly increased risk of idiopathic infertility with abnormal semen parameters in association with the variant rs2804535 and a decreased risk of idiopathic infertility with abnormal semen parameters in association with the variant rs11001334. However, among subjects with normal semen parameters, no significant differences could be found in these genotypes. Moreover, we could not find any differences in the variants rs7896741 and rs1259503, which showed no risk of male infertility, whether normal

SUBMITTER: Pan L 

PROVIDER: S-EPMC5347716 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature