Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes.

ABSTRACT: Exosomes are communication mediators participating in the intercellular exchange of proteins, metabolites and nucleic acids. Recent studies have demonstrated that exosomes are characterized by a unique proteomic composition that is distinct from the cellular one. The mechanisms responsible for determining the proteome content of the exosomes remain however obscure. In the current study we employ ultrastructural approach to validate a novel exosomal protein myoferlin. This is a multiple C2-domain containing protein, known for its conserved physiological function in endocytosis and vesicle fusion biology. Emerging studies demonstrate that myoferlin is frequently overexpressed in cancer, where it promotes cancer cell migration and invasion. Our data expand these findings by showing that myofe

SUBMITTER: Blomme A 

PROVIDER: S-EPMC5347796 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature