No evidence for homosubtypic immunity of influenza H3 in Mallards following vaccination in a natural experimental system.

ABSTRACT: The Mallard (Anas platyrhynchos) is an important reservoir species for influenza A viruses (IAV), and in this host, prevalence and virus diversity are high. Studies have demonstrated the presence of homosubtypic immunity, where individuals are unlikely to be reinfected with the same subtype within an autumn season. Further, evidence for heterosubtypic immunity exists, whereby immune responses specific for one subtype offer partial or complete protection against related HA subtypes. We utilized a natural experimental system to determine whether homo- or heterospecific immunity could be induced following experimental vaccination. Thirty Mallards were vaccinated with an inactivated H3, H6 or a sham vaccine and after seroconversion were exposed to naturally infected wild conspecifics. All duck

SUBMITTER: Wille M 

PROVIDER: S-EPMC5347849 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature