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Palladium(II)-Catalysed Aminocarbonylation of Terminal Alkynes for the Synthesis of 2-Ynamides: Addressing the Challenges of Solvents and Gas Mixtures.

ABSTRACT: 2-Ynamides can be synthesised through Pd^II catalysed oxidative carbonylation, utilising low catalyst loadings. A variety of alkynes and amines can be used to afford 2-ynamides in high yields, whilst overcoming the drawbacks associated with previous oxidative methods, which rely on dangerous solvents and gas mixtures. The use of [NBu₄ ]I allows the utilisation of the industrially recommended solvent ethyl acetate. O₂ can be used as the terminal oxidant, and the catalyst can operate under safer conditions with low O₂ concentrations.

SUBMITTER: Hughes NL

PROVIDER: S-EPMC5347853 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Palladium(II)-Catalysed Aminocarbonylation of Terminal Alkynes for the Synthesis of 2-Ynamides: Addressing the Challenges of Solvents and Gas Mixtures.

Hughes N Louise NL Brown Clare L CL Irwin Andrew A AA Cao Qun Q Muldoon Mark J MJ

ChemSusChem 20170123 4

2-Ynamides can be synthesised through PdII catalysed oxidative carbonylation, utilising low catalyst loadings. A variety of alkynes and amines can be used to afford 2-ynamides in high yields, whilst overcoming the drawbacks associated with previous oxidative methods, which rely on dangerous solvents and gas mixtures. The use of [NBu4 ]I allows the utilisation of the industrially recommended solvent ethyl acetate. O2 can be used as the terminal oxidant, and the ca ...[more]

PMID: 27906507

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