Differential gene expression patterns between smokers and non-smokers: cause or consequence?

ABSTRACT: The molecular mechanisms causing smoking-induced health decline are largely unknown. To elucidate the molecular pathways involved in cause and consequences of smoking behavior, we conducted a genome-wide gene expression study in peripheral blood samples targeting 18 238 genes. Data of 743 smokers, 1686 never smokers and 890 ex-smokers were available from two population-based cohorts from the Netherlands. In addition, data of 56 monozygotic twin pairs discordant for ever smoking were used. One hundred thirty-two genes were differentially expressed between current smokers and never smokers (P < 1.2 × 10^-6 , Bonferroni correction). The most significant genes were G protein-coupled receptor 15 (P < 1 × 10^-150 ) and leucine-rich repeat neuronal 3 (P < 1 × 10^-44

SUBMITTER: Vink JM 

PROVIDER: S-EPMC5347870 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature