Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis.

ABSTRACT:

Aim

Periodontitis is a chronic inflammatory disease, characterized by irreversible destruction of tooth-supporting tissue including alveolar bone. We recently reported mucin 4 (MUC4) and matrix metalloproteinase 7 (MMP7) as highly associated with periodontitis in gingival tissue biopsies. The aim of this study was to further investigate the levels of MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) samples of patients with periodontitis.

Materials and methods

Saliva and GCF samples were collected from periodontitis patients and healthy controls. The levels of MUC4, MMP7, and total protein concentrations were analysed using ELISA or Bradford assay.

Results

MUC4 levels were significantly lower in saliva and GCF from periodontitis patients relative to healthy

SUBMITTER: Lundmark A 

PROVIDER: S-EPMC5347886 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature