Heterogeneity of colorectal cancer risk by tumour characteristics: Large prospective study of UK women.

ABSTRACT: Associations between behavioural and other personal factors and colorectal cancer risk have been reported to vary by tumour characteristics, but evidence is inconsistent. In a large UK-based prospective study we examined associations of 14 postulated risk factors with colorectal cancer risk overall, and across three anatomical sites and four morphological subtypes. Among 1.3 million women, 18,518 incident colorectal cancers were identified during 13.8 (SD 3.4) years follow-up via record linkage to national cancer registry data. Cox regression yielded adjusted relative risks. Statistical significance was assessed using correction for multiple testing. Overall, colorectal cancer risk was significantly associated with height, body mass index (BMI), smoking, alcohol intake, physical activity,

SUBMITTER: Buron Pust A 

PROVIDER: S-EPMC5347941 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature