Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population.

ABSTRACT:

Background and purpose

Ischemic stroke (IS) is the main cause of mortality and disability among the old people in China and is a multifactorial disease influenced by many factors including genetic factors like the allele for CYP 2J2. It has been demonstrated that CYP2J2 polymorphisms alter the transcriptional activity. However, studies on the association between CYP2J2-50G/T polymorphism and IS have reported conflicting results. Thus, our study aimed to examine the association between 4 variants in the CYP2J2 gene and the risk of IS and its subtypes, in the Chinese population.

Materials and methods

In this study, genotyping was performed by using polymerase chain reaction (PCR) sequencing for 202 IS patients and 206 age- and sex-matched controls. Odds ratios (ORs) and confid

SUBMITTER: Wang SY 

PROVIDER: S-EPMC5348184 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature