Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study.

ABSTRACT:

Background

Epidemiological studies have reported associations between air pollution and neuro-psychological conditions. Biological mechanisms behind these findings are still not clear.

Objectives

We examined changes in blood and urinary neural biomarkers following exposure to concentrated ambient coarse, fine and ultrafine particles.

Methods

Fifty healthy non-smoking volunteers, mean age 28years, were exposed to coarse (2.5-10μm, mean 213μg/m³) and fine (0.15-2.5μm, mean 238μg/m³) concentrated ambient particles (CAPs), and filtered ambient and/or medical air. Twenty-five participants were exposed to ultrafine CAP (mean size 59.6nm, range 47.0-69.8nm), mean (136μg/m³) and filtered medical air. Exposures lasted 130min, separated by ≥2wee

SUBMITTER: Liu L 

PROVIDER: S-EPMC5348252 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature