Associations between urinary diphenyl phosphate and thyroid function.

ABSTRACT: Triphenyl phosphate (TPHP) is a commonly used organophosphate flame retardant and plasticizer with widespread human exposure. Data on health effects of TPHP are limited. Recent toxicological studies suggest TPHP may alter thyroid function. We used repeated measures to assess the temporal variability in urinary concentrations of the TPHP metabolite, diphenyl phosphate (DPHP), and to examine relationships between DPHP concentrations and thyroid hormones. We sampled 51 adults at months 1, 6, and 12 from 2010 to 2011. Urine samples were analyzed for DPHP. Serum samples were analyzed for free and total thyroxine (fT₄, TT₄), total triiodothyronine (TT₃), and thyroid stimulating hormone (TSH). We assessed variability in DPHP using intraclass correlation coefficien

SUBMITTER: Preston EV 

PROVIDER: S-EPMC5348264 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature