MiR-151-5p, targeting chromatin remodeler SMARCA5, as a marker for the BRCAness phenotype.

ABSTRACT: In recent years, the assessment of biomarkers useful for "precision medicine" has been a hot topic in research. The involvement of microRNAs in the pathogenesis of breast cancer has been highly investigated with the aim of being able to molecularly stratify this highly heterogeneous disease. Our aim was to identify microRNAs targeting DNA repair machinery, through Affymetrix GeneChip miRNA Arrays, in a cohort of BRCA-related and sporadic breast cancers. Moreover, we analyzed microRNA expression taking into account our previous results on the expression of PARP1, because of its importance in targeted therapy. miR-361-5p and miR-151-5p were found to be overexpressed in PARP1-upregulating BRCA-germline mutated and sporadic breast tumors. Pathway enrichment analysis was performed to identify p

SUBMITTER: Tommasi S 

PROVIDER: S-EPMC5348325 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature