The evaluation of immunotherapy and chemotherapy treatment on melanoma: a network meta-analysis.

ABSTRACT:

Background

Melanoma is a highly malignant tumor that develops from a neural crest derivative called melanocytes. Chemotherapy is recommended for patients with stage III/IV melanoma. Immunomodulation has also been shown to effectively improve the survival rate of such patients. In the current study, we aimed to perform a network meta-analysis on the therapeutic value of chemotherapy and immunotherapy on melanoma.

Results

Twenty randomized controlled trials (RCTs) were enrolled in the study. Our Results indicated that ipilimumab + nivolumab had the highest response rate among all therapies, pembrolizumab also had a good efficacy with an excellent tolerance. Chemotherapy had a low response rate, high adverse effects and progressive diseases qualities, therefore it is not recomm

SUBMITTER: CiRen B 

PROVIDER: S-EPMC5348408 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature