Identification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma.

ABSTRACT:

Background

Specific biomarkers for outcome prediction of lung squamous cell carcinoma (LUSC) are still lacking. This study assessed the prognostic value of differentially expressed miRNAs of LUSC patients.

Results

Twelve of the 133 most significantly altered miRNAs were associated with overall survival (OS) across different clinical subclasses of the Cancer Genome Atlas (TCGA) LUSC cohort. A linear prognostic model of seven miRNAs was developed to divide patients into high- and low-risk groups. Patients assigned to the high-risk group exhibited poor OS compared with patients in the low-risk group, which was further validated in the validation cohort and entire LUSC cohort.

Methods

MiRNA expression profiles with clinical information of 447 LUSC patients were obtained f

SUBMITTER: Gao X 

PROVIDER: S-EPMC5348421 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature