Growth hormone replacement therapy reduces risk of cancer in adult with growth hormone deficiency: A meta-analysis.

ABSTRACT: The risk of growth hormone on cancer in adult with growth hormone deficiency remains unclear. We carried out a meta-analysis to evaluate the risk of cancer in adult with and without growth hormone replacement therapy. We searched PubMed, Web of Science, China National Knowledge Infrastructure, and WanFang databases up to 31 July 2016 for eligible studies. Pooled risk ratio (RR) with 95% confidence interval (CI) was calculated using fixed-or random-effects models if appropriate. The Newcastle-Ottawa Scale was used to assess the study quality. Two retrospective and seven prospective studies with a total of 11191 participants were included in the final analysis. The results from fixed-effects model showed this therapy was associated with the deceased risk of cancer in adult with growth hormon

SUBMITTER: Li Z 

PROVIDER: S-EPMC5348436 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature