Canonical and Cross-reactive Binding of NK Cell Inhibitory Receptors to HLA-C Allotypes Is Dictated by Peptides Bound to HLA-C.

ABSTRACT:

Background

Human natural killer (NK) cell activity is regulated by a family of killer cell immunoglobulin-like receptors (KIRs) that bind human leukocyte antigen (HLA) class I. Combinations of KIR and HLA genotypes are associated with disease, including susceptibility to viral infection and disorders of pregnancy. KIR2DL1 binds HLA-C alleles of group C2 (Lys⁸⁰). KIR2DL2 and KIR2DL3 bind HLA-C alleles of group C1 (Asn⁸⁰). However, this model cannot explain HLA-C allelic effects in disease or the impact of HLA-bound peptides. The goal of this study was to determine the extent to which the endogenous HLA-C peptide repertoire can influence the specific binding of inhibitory KIR to HLA-C allotypes.

Results

The impact of HLA-C bound peptide on inhibitory KIR

SUBMITTER: Sim MJ 

PROVIDER: S-EPMC5348643 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature