Cell wall dynamics modulate acetic acid-induced apoptotic cell death of Saccharomyces cerevisiae.

ABSTRACT: Acetic acid triggers apoptotic cell death in Saccharomyces cerevisiae, similar to mammalian apoptosis. To uncover novel regulators of this process, we analyzed whether impairing MAPK signaling affected acetic acid-induced apoptosis and found the mating-pheromone response and, especially, the cell wall integrity pathways were the major mediators, especially the latter, which we characterized further. Screening downstream effectors of this pathway, namely targets of the transcription factor Rlm1p, highlighted decreased cell wall remodeling as particularly important for acetic acid resistance. Modulation of cell surface dynamics therefore emerges as a powerful strategy to increase acetic acid resistance, with potential application in industrial fermentations using yeast, and in biomedi

SUBMITTER: Rego A 

PROVIDER: S-EPMC5349133 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature