Effect of paraquat-induced oxidative stress on gene expression and aging of the filamentous ascomycete Podospora anserina

ABSTRACT: Aging of biological systems is influenced by various factors, conditions and processes. Among others, processes allowing organisms to deal with various types of stress are of key importance. In particular, oxidative stress as the result of the generation of reactive oxygen species (ROS) at the mitochondrial respiratory chain and the accumulation of ROS-induced molecular damage has been strongly linked to aging. Here we view the impact of ROS from a different angle: their role in the control of gene expression. We report a genome-wide transcriptome analysis of the fungal aging model Podospora anserina grown on medium containing paraquat (PQ). This treatment leads to an increased cellular generation and release of H₂O₂, a reduced growth rate, and a decrease in li

SUBMITTER: Wiemer M 

PROVIDER: S-EPMC5349155 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature