In Entamoeba histolytica, a BspA family protein is required for chemotaxis toward tumour necrosis factor.

ABSTRACT:

Background

Entamoeba histolytica cell migration is essential for the development of human amoebiasis (an infectious disease characterized by tissue invasion and destruction). The tissue inflammation associated with tumour necrosis factor (TNF) secretion by host cells is a well-documented feature of amoebiasis. Tumour necrosis factor is a chemoattractant for E. histolytica, and the parasite may have a TNF receptor at its cell surface.

Methods

confocal microscopy, RNA Sequencing, bioinformatics, RNA antisense techniques and histological analysis of human colon explants were used to characterize the interplay between TNF and E. histolytica.

Results

an antibody against human TNF receptor 1 (TNFR1) stained the E. histolytica trophozoite surface

SUBMITTER: Silvestre A 

PROVIDER: S-EPMC5349171 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature