Dataset Information

Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas.

ABSTRACT: Gliomas are the most common and lethal intracranial tumours. RNA sequencing technologies and advanced data analyses recently enabled the characterization of transcriptomic information, including protein-coding gene expression, non-coding gene expression, alternative splicing, and fusion gene detection, to facilitate detection of diseases and altered phenotypes. As a part of the Chinese Glioma Genome Atlas (CGGA) project, our aim was to delineate comprehensive transcriptome profiling in the malignant progression of human gliomas. Three hundred twenty five gliomas with different grades were collected over the past twelve years. Using the Illumina HiSeq 2,000 system, over 92 million high quality 101-bp paired-end reads were generated per sample, yielding a total of 30 billion reads. This comprehensive dataset will be useful to deepen the comprehensive understanding of gliomas, providing an opportunity to generate new therapies, diagnoses, and preventive strategies.

SUBMITTER: Zhao Z

PROVIDER: S-EPMC5349247 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas.

Zhao Zheng Z Meng Fanlin F Wang Wen W Wang Zheng Z Zhang Chuanbao C Jiang Tao T

Scientific data 20170314

Gliomas are the most common and lethal intracranial tumours. RNA sequencing technologies and advanced data analyses recently enabled the characterization of transcriptomic information, including protein-coding gene expression, non-coding gene expression, alternative splicing, and fusion gene detection, to facilitate detection of diseases and altered phenotypes. As a part of the Chinese Glioma Genome Atlas (CGGA) project, our aim was to delineate comprehensive transcriptome profiling in the malig ...[more]

PMID: 28291232

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Dataset Information

Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas.

Publications

Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas.

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