Spatial and quantitative datasets of the pancreatic β-cell mass distribution in lean and obese mice.

ABSTRACT: A detailed understanding of pancreatic β-cell mass distribution is a key element to fully appreciate the pathophysiology of models of diabetes and metabolic stress. Commonly, such assessments have been performed by stereological approaches that rely on the extrapolation of two-dimensional data and provide very limited topological information. We present ex vivo optical tomographic data sets of the full β-cell mass distribution in cohorts of obese ob/ob mice and their lean controls, together with information about individual islet β-cell volumes, their three-dimensional coordinates and shape throughout the volume of the pancreas between 4 and 52 weeks of age. These data sets offer the currently most comprehensive public record of the β-cell mass distribution in the mouse. As such, they may

SUBMITTER: Parween S 

PROVIDER: S-EPMC5349252 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature