Transcriptomic profiling of human hippocampal progenitor cells treated with antidepressants and its application in drug repositioning.

ABSTRACT: Current pharmacological treatments for major depressive disorder (MDD) are ineffective in a significant proportion of patients, and the identification of new antidepressant compounds has been difficult. 'Connectivity mapping' is a method that can be used to identify drugs that elicit similar downstream effects on mRNA levels when compared to current treatments, and thus may point towards possible repositioning opportunities. We investigated genome-wide transcriptomic changes to human hippocampal progenitor cells treated with therapeutically relevant concentrations of a tricyclic antidepressant (nortriptyline) and a selective serotonin reuptake inhibitor (escitalopram). We identified mRNA changes common to both drugs to create an 'antidepressant mRNA signature'. We used this signature to pr

SUBMITTER: Powell TR 

PROVIDER: S-EPMC5349314 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature