Revisiting Hartert's 1962 Calculation of the Physical Constants of Thrombelastography.

ABSTRACT: Thrombelastography (TEG)/thromboelastometry (ROTEM) devices measure viscoelastic clot strength as clot amplitude (A). Transformation of clot amplitude into clot elasticity (E with TEG; CE with ROTEM) is sometimes necessary (eg, when calculating platelet component of the clot). With TEG, clot amplitude is commonly transformed into shear modulus (G; expressed in Pa or dyn/cm²) as follows: G = (5000 × A)/(100 - A). Use of the constant "5000" stems from Hartert's 50-year-old calculation of G for a normal blood clot. We question the value of calculating G as follows: (1) It may be questioned whether TEG/ROTEM analysis enable measurement of elasticity because viscosity may also contribute to clot amplitude. (2) It has been suggested that absolute properties of a blood clot cannot be m

SUBMITTER: Hochleitner G 

PROVIDER: S-EPMC5349316 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature