Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array.

ABSTRACT: The balance between acetylation and deacetylation of histone proteins plays a critical role in the regulation of genomic functions. Aberrations in global levels of histone modifications are linked to carcinogenesis and are currently the focus of intense scrutiny and translational research investments to develop new therapies, which can modify complex disease pathophysiology through epigenetic control. However, despite significant progress in our understanding of the molecular mechanisms of epigenetic machinery in various genomic contexts and cell types, the links between epigenetic modifications and cellular phenotypes are far from being clear. For example, enzymes controlling histone modifications utilize key cellular metabolites associated with intra- and extracellular feedback loops, ad

SUBMITTER: Partolina M 

PROVIDER: S-EPMC5349387 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature