ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells.

ABSTRACT: Mesenchymal stem cells (MSCs) can modulate lymphocyte proliferation and function. One of the immunomodulatory functions of MSCs involves CD4⁺CD25⁺FoxP3⁺ regulatory T cells (Tregs), which negatively regulate inflammatory responses. MSC-mediated Treg induction is supposed to be regulated by mechanisms requiring both soluble and cell contact-dependent factors. Although the involvement of soluble factors has been revealed, the contact-dependent mechanisms in MSC-mediated Treg induction remain unclear. We attempted to identify molecule(s) other than secreted factors that are responsible for MSC-mediated Treg induction and to uncover the underlying mechanisms. Under in vitro Treg-inducing conditions, ICOSL expression in MSCs coincided with Treg induction in co-cu

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC5349520 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature