Physiological and pathological high-frequency oscillations have distinct sleep-homeostatic properties.

ABSTRACT:

Objective

The stage of sleep is a known modulator of high-frequency oscillations (HFOs). For instance, high amplitude slow waves during NREM sleep and the subtypes of REM sleep were shown to contribute to a better separation between physiological and pathological HFOs. This study investigated rates and spatial spread of the different HFO types (physiological and pathological ripples in the 80-250 Hz frequency band, and fast ripples above 250 Hz) depending on time spent in sleep across the different sleep cycles.

Methods

Fifteen patients with focal pharmaco-resistant epilepsy underwent one night of video-polysomnography during chronic intracranial EEG recording for presurgical epilepsy evaluation. The HFO rate and spread across the different sleep cycles were determined with

SUBMITTER: von Ellenrieder N 

PROVIDER: S-EPMC5349616 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature